1-[2-[4-(Chloromethyl) phenyl] ethyl]hexahydro-1H-azepine is an organic compound, usually denoted by the abbreviation CMHEA (phenyl). The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless liquid or solid.
-Molecular formula: C14H22ClNO
-Molecular weight: 255.78g/mol
-Boiling point: About 238-241 ° C
-Density: about 1.097g/cm³
-Solubility: Slightly soluble in water, soluble in organic solvents such as methanol and ethanol.
Use:
1-[2-[4-(Chloromethyl) phenyl] ethyl]hexahydro-1H-azepine are commonly used as intermediates in organic synthesis and have two main application fields:
-Agricultural field: can be used for synthetic pesticides, herbicides, fungicides, etc.
-Pharmaceutical field: It can be used to synthesize anti-cancer drugs, anti-infective drugs, analgesic drugs, etc.
Method:
The preparation of 1-[2-[4-(Chloromethyl) phenyl] ethyl]hexahydro-1H-azepine is usually carried out by the following steps:
1. Chloroethanol reacts with chloromethylphenol under alkaline conditions to generate the corresponding chloromethylphenol ether estrone compound.
2. The compound is reacted with chloroethanol to generate 1-[2-[4-(Chloromethyl) phenyl] ethyl]hexahydro-1H-azepine.
Safety Information:
1-[2-[4-(chlorine methyl) phenyl] ethyl]hexahydro-1H-azepine is a chemical substance that should be handled and stored in a suitable laboratory environment. Here are some recommended safety considerations:
-Avoid contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment such as lab gloves, safety glasses and protective masks when operating.
-Operate in a well-ventilated place to avoid inhaling its vapor or dust.
-Comply with regulations for storage and handling of chemicals.
Please note that the above information is for reference only, and please follow the specific experimental conditions and safety regulations.